Research Issues Involving the Biology of Autism

Edelson, Stephen M.

doi:10.17759/autdd.2019170102

Autism and Developmental Disorders

2019

DOI: 10.17759/autdd.2019170102

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Research Issues Involving the Biology of Autism

Stephen M. Edelson

Abstract: This article provides an overview and discussion on many of the major topics currently discussed in the autism research community. These topics include: prevalence, male-to-female ratio, diagnosis, genetics, environmental factors, neurology, medical comorbidities, sensory processing, and behavior. The article concludes with a discussion of future research in the field of autism.

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2020

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On the mechanisms of the occurrence of autism spectrum disorders: a family case report

Tyushkevich

Mamokhina

Danilina³

et al. 2020

Autism and Developmental Disorders

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Currently, more than 1000 genes described in which mutations are observed in autism spectrum disorders. Neurobiological predictors have been found to presume these abnormalities in early postnatal ontogenesis. However, the mechanisms of the occurrence of these genetic abnormalities remain unclear. This is connected to the particular interest in the description of family cases in which ASD in combination with various genome features are observed. The data of a five-year comprehensive psychological and neurophysiological study of three siblings with various developmental features and genetic disorders inherited from the father are presented. The results revealed that all children showed an increase in altered chromosome regions inherited from their father. However, only in the case of an increase in repeats in chromosome 8, autism spectrum disorder was diagnosed in a child. Changes in the Y chromosome, apparently, are not associated with detected developmental disorders in two other children.

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On the mechanisms of the occurrence of autism spectrum disorders: a family case report

Tyushkevich

Mamokhina

Danilina³

et al. 2020

Autism and Developmental Disorders

View full text Add to dashboard Cite

show abstract

Gastrointestinal Tract Symptomatology in Adults with Pica and Autism

Alexander

Lunde

Berger

2020

Autism and Developmental Disorders

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This study investigated pica behavior in those with and without autism in relation to gastrointestinal (GI) tract symptomatology and disease. A chart review of 64 residential adults with developmental disabilities indicated that individuals with pica had more GI tract diseases, and those with autism and pica had a higher rate of GI diseases compared to those with autism and no pica behavior. These data suggest that individuals with both autism and pica disorders may be a phenotypic subgroup in the autistic spectrum characterized by GI symptomatology, requiring a clinical algorithm for categorization and effective treatment. A behavior-analytic model is presented that conceptualizes pica as part of a chain of events that begins with exploratory behavior and culminates in GI symptomatology and disease. Issues of sensory processing are addressed within this model. Individuals exhibiting pica may benefit from gastrointestinal evaluation, including assessment of the microbiome, and, if indicated, microbiota transfer therapy to

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Research Issues Involving the Biology of Autism

Cited by 2 publications

References 45 publications

On the mechanisms of the occurrence of autism spectrum disorders: a family case report

On the mechanisms of the occurrence of autism spectrum disorders: a family case report

Gastrointestinal Tract Symptomatology in Adults with Pica and Autism

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