Research Leads to Approved Therapies in the New Era of Living Medicine

Nolta, Jan A.

doi:10.1002/stem.2748

Stem Cells

2017

DOI: 10.1002/stem.2748

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Research Leads to Approved Therapies in the New Era of Living Medicine

Jan A. Nolta¹

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2024

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Cited by 1 publication

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Super-enhancer omics in stem cell

Ma,

Qu,

Pang

et al. 2024

Mol Cancer

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The hallmarks of stem cells, such as proliferation, self-renewal, development, differentiation, and regeneration, are critical to maintain stem cell identity which is sustained by genetic and epigenetic factors. Super-enhancers (SEs), which consist of clusters of active enhancers, play a central role in maintaining stemness hallmarks by specifically transcriptional model. The SE-navigated transcriptional complex, including SEs, non-coding RNAs, master transcriptional factors, Mediators and other co-activators, forms phase-separated condensates, which offers a toggle for directing diverse stem cell fate. With the burgeoning technologies of multiple-omics applied to examine different aspects of SE, we firstly raise the concept of “super-enhancer omics”, inextricably linking to Pan-omics. In the review, we discuss the spatiotemporal organization and concepts of SEs, and describe links between SE-navigated transcriptional complex and stem cell features, such as stem cell identity, self-renewal, pluripotency, differentiation and development. We also elucidate the mechanism of stemness and oncogenic SEs modulating cancer stem cells via genomic and epigenetic alterations hijack in cancer stem cell. Additionally, we discuss the potential of targeting components of the SE complex using small molecule compounds, genome editing, and antisense oligonucleotides to treat SE-associated organ dysfunction and diseases, including cancer. This review also provides insights into the future of stem cell research through the paradigm of SEs.

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Super-enhancer omics in stem cell

Ma,

Qu,

Pang

et al. 2024

Mol Cancer

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Research Leads to Approved Therapies in the New Era of Living Medicine

Cited by 1 publication

References 39 publications

Super-enhancer omics in stem cell

Super-enhancer omics in stem cell

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