Research Letters

Nair, Smita K.; Singh, Amitabh; Jajoo, Mamta; Yadav, Pallavi; Sharma, Pankaj; Arora, Rohit

doi:10.1007/s13312-018-1268-6

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…The data were entered in MS Excel (Microsoft Corporation, Redmond, WA) spreadsheet and analysis was done using Statistical Package for Social Sciences (SPSS; IBM, Armonk, NY) licensed version 21.0. Sample size calculation was based on a previous study done by Nair S et al 17 The study showed the hospital-based period prevalence of hypernatremic dehydration as 3.4%. Taking this value as reference, the minimum required sample size at 95% confidence interval and 5% margin of error was 55 patients.…”

Section: Methodsmentioning

confidence: 99%

Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department

Tanwar,

Kapoor,

Kumar

et al. 2023

Pediatr Emer Care

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Objectives The aim of this study was to evaluate the clinical profile and outcome of young infants presenting to the pediatric emergency department with hypernatremic dehydration. Methods A prospective observational study was conducted at a tertiary care teaching hospital over a period of 18 months. All outborn sick young infants aged 2 months or younger who presented to the emergency department with symptoms and signs of possible sepsis and/or dehydration were screened, and those with hypernatremia were enrolled in the study. Those infants born at less than 37 weeks of gestation and gross congenital anomaly were excluded. Hypernatremic dehydration was defined as serum sodium levels (Se Na+)higher than 145 mEq/L. Variables used in the study were defined as per standard definitions. Acute kidney injury was defined and staged using serum creatinine as per modified neonatal Kidney Disease Improving Global Outcome guidelines. Clinical presentation, laboratory parameters, and comorbidities were compared among outcome groups (survived and died). Results Of 1124 outborn young infants who met the eligibility criteria for screening, 63 were diagnosed to have hypernatremic dehydration and 55 were enrolled. The hospital-based period prevalence of hypernatremic dehydration in young infants was 4.89%. The median age of presentation was 17 days (10–30). Male-to-female ratio was 1.1:1. Seventy-three percent were first in birth order. Feeding pattern showed 61.8%, 30.9%, and 7.3% of infants were exclusively breastfed, top fed, and mixed fed, respectively. The median serum sodium at the time of admission was 160 (153.5–167) mg/dL. Three (5.5%) infants had mild, 39 (70.9%) had moderate, and 13 (23.6%) had severe hypernatremic dehydration. There was statistically significant correlation between median platelet count with severity of hypernatremic dehydration. The mean time taken to correct serum sodium level was 3.30 ± 1.60 days. The case fatality rate was 41.8%. Those who died had statistically more severe hypernatremic dehydration, acute kidney injury, sepsis, and need for ventilation. Conclusions Acute kidney injury stage 3, shock, and need for ventilation are associated with poor outcome in infants with hypernatremic dehydration

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Section: Methodsmentioning

confidence: 99%

Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department

Tanwar,

Kapoor,

Kumar

et al. 2023

Pediatr Emer Care

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“…La hipernatremia (sodio sérico 145 mEq/L) es un desequilibrio que, cuando es grave (160 mEq/L), puede causar alteraciones vasculares y neurológicas agudas, dejar secuelas graves o causar la muerte en recién nacidos. [1][2][3][4] Se han descrito: trombosis del seno sagital superior, 5-6 aórtica 7-8 mesentérica, renal, iliaca, femoral, poplítea 7 y arteria retinal; 9 hemorragia parenquimatosa, 10 gangrena distal, 7,[11][12] enterocolitis necrosante, 13 hipertensión arterial pulmonar e insuficiencia cardiaca derecha. 14 La patogénesis de las lesiones cerebrales se describió hace más de medio siglo, 15 muchas secundarias a una corrección inadecuada.…”

Section: Antecedentesunclassified

Tratamiento individualizado de la deshidratación hipernatrémica en el recién nacido

Candiani

2019

Acta Pediatr Mex

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La hipernatremia (sodio sérico 145 mEq/L) es un desequilibrio que, cuando es grave (160 mEq/L), puede causar alteraciones vasculares y neurológicas agudas, dejar secuelas graves o causar la muerte en recién nacidos.1-4 Se han descrito: trombosis del seno sagital superior,5-6 aórtica 7-8 mesentérica, renal, iliaca, femoral, poplítea7 y arteria retinal;9 hemorragia parenquimatosa,10 gangrena distal,7,11-12 enterocolitis necrosante,13 hipertensión arterial pulmonar e insuficiencia cardiaca derecha.14 La patogénesis de las lesiones cerebrales se describió hace más de medio siglo,15 muchas secundarias a una corrección inadecuada. Oddie16 informa una incidencia de 7 x cada 100,000 nacidos vivos. Se trata, en sí, de un trastorno de la concentración relativa de sodio en el espacio extracelular, y no necesariamente de la cantidad de sodio corporal total que puede estar elevada o ser normal; puede asociarse con volumen de agua corporal normal, alto o bajo.

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Acute kidney injury in sick neonates: a comparative study of diagnostic criteria, assessment of risk factors and outcomes

Hamsa

Nesargi

Prashantha

et al. 2020

The Journal of Maternal-Fetal & Neonatal Medicine

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Research Letters

Cited by 3 publications

References 10 publications

Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department

Clinical Profile and Outcome of Young Infants With Hypernatremic Dehydration Presenting to the Emergency Department

Tratamiento individualizado de la deshidratación hipernatrémica en el recién nacido

Acute kidney injury in sick neonates: a comparative study of diagnostic criteria, assessment of risk factors and outcomes

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