Research needs and prioritizations for studies linking dietary sugars and potentially related health outcomes

Chung, Mei; Wang, Ding Ding; Archer, Edward; Higgins, Janine; Kim, Sery; Laughlin, Maren R.; Qi, Lü; Raatz, Susan K.; Siegel, Richard D.; Slavin, Joanne L.; Steffen, Dan; Warshaw, Hope; Tang, Alice

doi:10.1186/s40795-016-0108-0

Cited by 4 publications

(6 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the basis of these results, we concluded that the research trends and research gaps have not changed since 2013, when the evidence-map database was updated. Therefore, the 14 prioritized research questions (research needs) in the broad field of dietary sugars and health outcomes remain valid ( Supplemental Table 2 ) ( 11 ). These 14 high-priority research questions were identified by a multidisciplinary stakeholder panel following a structured approach that integrated evidence mapping with expertise or viewpoints from the panel.…”

Section: Discussionmentioning

confidence: 99%

“…Search results were limited to English-language, peer-reviewed human intervention studies and prospective cohort (PC) studies published from January 2013 to December 2016 ( Supplemental Table 1 ). This was the same search strategy and study eligibility criteria utilized in creating the 2013 evidence-map database ( 11 ). We did not search for or include any unpublished studies, clinical trial registries, or gray literature such as government or organization reports.…”

Section: Methodsmentioning

confidence: 99%

“…Keeping databases up to date is crucial to best leverage this method and to facilitate translation of scientific knowledge into policy or practice ( 6 ). In 2013, an open evidence-map database of all published studies on dietary sugars and select health outcomes was created (herein referred to as “the 2013 evidence-map database”; available from http://srdr.ahrq.gov/projects/136 ) as an integral part of a research prioritization project by a multidisciplinary stakeholder panel ( 11 ). Given the recent proliferation of research on dietary sugars, the increasing interest in their potential health effects, and the importance of this public health topic, the World Sugars Research Organization commissioned an update of the 2013 evidence-map database ( 11 ), with a goal of explicating research trends and gaps.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An Evidence Map of Research Linking Dietary Sugars to Potentially Related Health Outcomes

Tybor

Beauchesne

Niu

et al. 2018

Current Developments in Nutrition

Self Cite

View full text Add to dashboard Cite

BackgroundEvidence mapping is an emerging tool used to systematically identify, organize, and summarize the quantity, distribution, and characteristics of published studies with the goal of identifying knowledge gaps and future research needs.ObjectiveThe aim of the study was to present an evidence-map database of all published studies that investigated dietary sugars and to select health outcomes for explicating research trends and gaps.MethodsTo update an evidence-map database previously published in 2013, we performed a literature search in MEDLINE to identify English-language, peer-reviewed human intervention and prospective cohort studies published from January 2013 to December 2016. Abstracts and full-text articles were dual screened on the basis of predefined eligibility criteria. We classified outcomes into 7 health outcome categories that are potentially affected by dietary sugar. Data from the updated evidence-map database were merged with those from the previous database for analysis and charting.ResultsThere were 918 sugar and control intervention arms from a total of 298 intervention studies from 1966 to December 2016. A variety of sugar interventions were investigated across the included intervention studies, and it appears that the research interest across all outcome categories (cardiovascular disease risks, diabetes risks, body weight, body composition, appetite, dietary intake, and liver health–related outcomes) sharply increased from 2006. Bubble plots showed research gaps in long-term intervention studies and in intervention studies in patients with diabetes. In contrast, all 25 included cohort studies had long-term follow-up durations and much larger sample sizes than did intervention studies. None of the cohort studies evaluated dietary intake outcomes, and only one cohort study each examined appetite- and liver health–related outcomes.ConclusionsThe research trends and research gaps have not changed since 2013 when the original evidence-map database was updated. With continuous updating, evidence mapping can facilitate the process of knowledge translation and possibly reduce research waste.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An Evidence Map of Research Linking Dietary Sugars to Potentially Related Health Outcomes

Tybor

Beauchesne

Niu

et al. 2018

Current Developments in Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

“…A diet high in added sugars has been linked to a variety of health problems, including obesity [4], cardiovascular disease [5] and type 2 diabetes [6]. Despite the causal relationship reported between total and added sugars intake and a variety of chronic diseases, there exists some uncertainties as to the accuracy of these conclusions [7,8]. Research prioritization for studies that link dietary sugars with potentially related health outcomes continues to be an important area of investigation [9].…”

Section: Introductionmentioning

confidence: 99%

Sugar Loss Attributed to Non-Enzymatic Browning Corresponds to Reduce Calories Recovered in Low-Molecular-Weight Fraction

Liang¹,

Chen²,

Kitts³

2018

J Nutr Food Sci

View full text Add to dashboard Cite

Health agencies state that total dietary energy intake should not exceed a maximal of 25% of calories derived from added sugars. Bakery products are major food sources that contribute to the added sugars intake; however potential sugars losses due to Maillard reaction and caramelization, occur at typical baking temperatures. In this study we employed markers associated with non-enzymatic browning, that corresponded to loss of free sugars, generation of α-dicarbonyl compounds with changes in caloric content of digestible constituents in sugar-amino acid model and cake formulations. Sugars losses in simple model systems that reached 100 percent after 40 min baking at baking temperatures of 150°C and 180°C corresponded to reduced calorie content, in fractions with a MW<3000 (p<0.05). In comparison, less gross energy calories from sucrose were lost after a similar heat treatment in sucroseamino acid mixtures. Model cakes baked at 150°C and 180°C, respectively followed this trend with invert sugar, having greater losses losses (p<0.01) than cakes containing sucrose. We conclude that thermal temperatures typical of baking that result in non-enzymatic browning reactions, reduce both the total sugars and corresponding calories due to conversation to non-bioavailable high molecular weight browning products.

show abstract

“…Furthermore, nutrition-related systematic reviews only comprise ∼8% of all systematic reviews in the Cochrane Database of Systematic Reviews and, among these, approximately half focus on nutritional supplementation or supplements ( 3 ). Due to the anticipated need to consider broader research questions for public health nutrition, we previously modified the ARHQ's FRN approach by integrating an evidence-mapping process ( 4 ). Evidence mapping is an emerging evidence synthesis method for describing the volume and characteristics of research in a broad field.…”

Section: Introductionmentioning

confidence: 99%

Research Priorities for Studies Linking Intake of Low-Calorie Sweeteners and Potentially Related Health Outcomes

Bright

Wang

Shams-White

et al. 2017

Current Developments in Nutrition

Self Cite

View full text Add to dashboard Cite

Background: In a world of finite research funding, efforts to prioritize future research topics are increasingly necessary. Objective: The aim of this study was to identify and prioritize the direction of future research in the broad area of low-calorie sweetener (LCS) intake and potentially related health outcomes by using a novel method that incorporates evidence mapping in the Agency for Healthcare Research and Quality's Future Research Needs (FRN) process. Methods: A diverse expert stakeholder panel was convened and engaged to identify research gaps and prioritize future research needs. An independent research team hosted a number of interactive webinars and elicited feedback through surveys and individual interviews with the stakeholder panel, which included policymakers, lay audience members, health providers, a research funder, individuals with food industry experience, and researchers of several different specialties. Results: The stakeholder panel generated and ranked a list of 18 FRN questions across 5 broad research areas. Overall, stakeholder panel members unanimously agreed that the research questions that will have the largest public health impact are those that address outcomes related to body weight, appetite, and dietary intake. Although the LCSs included in this FRN project have all been Generally Recognized as Safe by the FDA or approved as food additives, the recurrent concerns and confusions with regard to the “safety” of LCSs by consumers underscore the importance of communicating the science to the general public. Conclusion: Our project provides evidence that engaging a diverse expert stakeholder panel is an effective method of translating gaps in nutrition research into prioritized areas of future research.

show abstract

Research needs and prioritizations for studies linking dietary sugars and potentially related health outcomes

Cited by 4 publications

References 33 publications

An Evidence Map of Research Linking Dietary Sugars to Potentially Related Health Outcomes

An Evidence Map of Research Linking Dietary Sugars to Potentially Related Health Outcomes

Sugar Loss Attributed to Non-Enzymatic Browning Corresponds to Reduce Calories Recovered in Low-Molecular-Weight Fraction

Research Priorities for Studies Linking Intake of Low-Calorie Sweeteners and Potentially Related Health Outcomes

Contact Info

Product

Resources

About