Alpha-amylase improves carbohydrate digestion, increasing the available energy to maximize the performance of broiler chickens. This study evaluated the inclusion of alpha-amylase in diets with metabolizable energy (ME) valorization on growth performance, carcass yield, and intestinal health of broiler chickens. A total of 640 male broiler chickens (Cobb 500) were distributed in a completely randomized design with four treatments and eight repetitions of 20 birds each. The treatments were: PC (positive control), NC (negative control with a reduction of 100 kcal ME per kg diet), 100g-AA (NC + 100 g alpha-amylase per kg of diet), and 200g-AA (NC + 200 g alpha-amylase per kg diet). At 42 days, broiler chickens in the PC and supplemented groups (100g-AA and 200g-AA) showed better ME utilization, and at 21 and 42 days, greater weight gain (P<0.05). Broiler chickens supplemented with 100g-AA and 200g-AA had better digestibility of dry matter, ash, and gross energy (P<0.05) at 42 days. The ileal digestibility of starch was higher in the 100g-AA and 200g-AA groups compared to the PC group (P<0.10) at 42 days. The concentration of butyric acid in the cecal content was higher in the 200g-AA group compared to the PC group (P<0.05) at 35 days. Supplementation of alpha-amylase in diets with reduced ME is a viable strategy to optimize the performance of broiler chickens.