Research Note: The effect of photoperiod on the NLRP3 inflammasome and gut microbiota in broiler chickens

Ma, Dandan; Yu, Miao; Zhang, Minhong; Feng, Jinghai

doi:10.1016/j.psj.2024.103507

Cited by 1 publication

(3 citation statements)

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“…Light pollution is a potential risk factor for animal and human health [ 26 ]. It has been reported that prolonged exposure to light can lead to intestinal inflammation [ 8 , 15 ]. However, the understanding of its underlying mechanism is not comprehensive.…”

Section: Discussionmentioning

confidence: 99%

“…An increased level of TNF-α was found in layer ducks under the condition of prolonged exposure to light [ 7 ]. In addition, a previous study in our laboratory found that extended exposure to light (23L:1D) significantly increased the content of inflammatory cytokines in the intestine and disrupted the morphology of intestine tissue, which leads to intestinal inflammation in broiler chickens [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…The gut microbiota can recognize immune regulatory proteins such as anti-inflammatory cytokines and pro-inflammatory cytokines through PRRs, which play important roles in inflammatory responses [ 22 ]. In a previous study in our laboratory, it was found that under the condition of extended exposure to light, the NLRP3 inflammasome may interact with the gut microbiota, leading to intestinal inflammation in broiler chickens [ 8 ]. Thus, we hypothesized that the NLRP3 inflammasome may be an important pathway between the gut microbiota and intestinal inflammation induced by extended exposure to light.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens

Ma,

Zhang,

Feng

2024

IJMS

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Light pollution is a potential risk for intestinal health in humans and animals. The gut microbiota is associated with the development of intestinal inflammation induced by extended exposure to light, but the underlying mechanism is not yet clear. The results of this study showed that extended exposure to light (18L:6D) damaged intestinal morphology, downregulated the expression of tight junction proteins, and upregulated the expression of the NLRP3 inflammasome and the concentration of pro-inflammatory cytokines. In addition, extended exposure to light significantly decreased the abundance of Lactobacillus, Butyricicoccus, and Sellimonas and increased the abundance of Bifidobacterium, unclassified Oscillospirales, Family_XIII_UCG-001, norank_f__norank_o__Clostridia_vadinBB60_group, and Defluviitaleaceae_UCG-01. Spearman correlation analysis indicated that gut microbiota dysbiosis positively correlated with the activation of the NLRP3 inflammasome. The above results indicated that extended exposure to light induced intestinal injury by NLRP3 inflammasome activation and gut microbiota dysbiosis. Antibiotic depletion intestinal microbiota treatment and cecal microbiota transplantation (CMT) from the 12L:12D group to 18L:6D group indicated that the gut microbiota alleviated intestinal inflammatory injury induced by extended exposure to light via inhibiting the activation of the NLRP3 inflammasome. In conclusion, our findings indicated that the gut microbiota can alleviate intestinal inflammation induced by extended exposure to light via inhibiting the activation of the NLRP3 inflammasome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%