The article is devoted to the problem of ensuring environmental safety in the territories of large cities, primarily, to reducing atmospheric air pollution. The aim of the work was to build a comprehensive classification scheme of sources of pollutant emissions into the air basin of the territories of large cities, taking into account the climatic and physicalgeographical conditions of the considered urban areas. In the process of research, we solved the problem of identifying the basic principles of classification of air pollution sources based on the analysis of known methodological approaches with the subsequent improvement of calculation methods to justify the spatial distribution of residential areas, industrial areas, motorways, recreational areas, effective sanitary protective zones taking into account aerodynamics to remove polluted air outside the city territory. A generalized classification of sources of pollutant emissions into the environment is proposed, while the sources of air pollution in urban areas are classified according to the following main criteria: by origin, by aerodynamic parameters and by the nature of the direction of the emission plume, by spatial position and possible mobility, in terms of size in plan, in height of the spread of the emission plume, taking into account the height of the mouth of the source of the emission of pollutants above the level of the earth’s surface, in temperature of air-gas mixture, according to the mode of action.