Bi-layered metallic bending tubes are widely used in extreme environments. The spring-back prediction theory for precise forming of such tube configuration is lacking. The layered coupling causes complex section internal force and new boundary conditions. This work proposed a theoretical prediction model of bimetallic tubes’ spring-back under computer numerically controlled (CNC) bending. This model calculated the spring-back angle by importing two new parameters—the composite elastic modulus (Ec) and the composite strain neutral layer (Dε). To investigate Dε, the neutral layer shifting extraction method was proposed to get the shifting value from finite element simulations. Simulations and full-scale bending experiments were carried out to verify the reliability of this prediction model. The theoretical results are closer to the experimental results than the finite element (FE) results and the theoretical results neglecting neutral layer shifting. The change of spring-back angle with the interlaminar friction coefficient was investigated. The results indicated that the normal mechanical bonding bimetallic tube with an interlaminar friction coefficient below 0.3 can reduce spring-back.