Research of Cu-Doped Hydroxyapatite Microbeads Fabricated by Pneumatic Extrusion Printing

Chi, Wenchao; Zou, Jiawei; Ai, Fanrong; Lin, Yanjun; Li, Wen Chao; Cao, Chuanliang; Yang, Kang; Zhou, Kui

doi:10.3390/ma12111769

Cited by 9 publications

(5 citation statements)

References 26 publications

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“…Such a significant weight loss of 42.61% is probably attributed to the BSA-templated copper nanoclusters present in HAPs, which were gradually removed from the nanoparticles. Further, between 900 and 1100 °C, there was another minor weight loss, possibly due to the dehydroxylation behavior of hydroxyapatite nanoparticles. − …”

Section: Resultsmentioning

confidence: 99%

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Simon

Chattopadhyay

Ghosh

2022

ACS Appl. Bio Mater.

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Imminent prospects of clinical importance have been accomplished through divergent treatment modalities implemented using nanoscale platforms. In the present study, hydroxyapatite nanoparticles doped with copper nanoclusters (HAPs) were explored for codelivery of a hydrophobic drug, namely, norfloxacin (NX), and a hydrophilic photosensitizer, such as methylene blue (MB). NX and MB were successfully homed into HAPs (MB-NX-HAPs), which further exhibited a pH-dependent release of both. With the objective of attaining an enhanced effect, MB-NX-HAPs were evaluated for combination therapy, involving chemotherapy and photodynamic therapy (PDT) with irradiation at 640 nm. The combinatorial therapy approach was initially applied for antibacterial therapy, which suggested a considerable reduction in bacterial growth of Gram-negative strain Pseudomonas aeruginosa MTCC 2488. Thereafter, the antiproliferative study performed in cancer cell lines (HeLa and MCF-7) revealed the efficiency of MB-NX-HAPs in bestowing a combinatorial effect through chemotherapy and PDT (irradiation at 640 nm). The combined effect exerted through MB-NX-HAPs subsequently induced reactive oxygen species (ROS) generation, cell cycle alteration, and apoptosis activation in cancer cells. The biocompatible nature of MB-NX-HAPs was appreciably shown through their minimal effect on the normal cell line (HEK-293). Additionally, HAPs through luminescence of copper nanoclusters were suggested to aid in bioimaging of cancer cell lines.

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Section: Resultsmentioning

confidence: 99%

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Simon

Chattopadhyay

Ghosh

2022

ACS Appl. Bio Mater.

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“…Pojava mikroorganizama na površini implantanta nakon ugradnje je veoma česta pojava, što je usmerilo brojne istraživače ka proučavanjima uticaja jona dopanata (bakra, cinka, srebra, itd.) na antimikrobna svojstva biomaterijala [12,13] Cink je esencijalan mikroelement, prisutan je u kostima i usko je povezan sa metabolizmom kostiju. Prisustvo jona cinka pospešuje bioaktivnost, biokompatibnost, promoviše proliferaciju osteoblasnih ćelija, izlučivanje osteokalcina i mineralizaciju okolnog koštanog tkiva [12,13].…”

Section: Uvodunclassified

“…na antimikrobna svojstva biomaterijala [12,13] Cink je esencijalan mikroelement, prisutan je u kostima i usko je povezan sa metabolizmom kostiju. Prisustvo jona cinka pospešuje bioaktivnost, biokompatibnost, promoviše proliferaciju osteoblasnih ćelija, izlučivanje osteokalcina i mineralizaciju okolnog koštanog tkiva [12,13]. Hidroksiapatit dopiran bakrom pospešuje proliferaciju koštanih ćelija, ali i obezbeđuje lokalnu antimikrobnu aktivnost.…”

Section: Uvodunclassified

Processing and properties of scaffolds based on calcium phosphate doped with magnesium, copper and zinc-ions coated with gelatin

Dragutinović,

Dimitrijević-Branković,

Veljović

2023

Tehnika

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The main goal of this study was to examine the possibility for obtaining macroporous scaffolds with defined properties based on calcium phosphate doped with magnesium, copper and zinc ions, coated with gelatin, which would potentially provide controlled conditions for the formation of new bone tissue after implantation. As a first, multi-doped nanoparticles of hydroxyapatite (HAp), which represents the main component of the inorganic part of bone tissue, was synthesized by autoclaving the precursor solution obtained at a Ca/P molar ratio of 1.52. Calcium in the initial solution was partially replaced by ions of magnesium (5 mol.%), copper (0.4 mol.%) and zinc (0.4 mol.%). Obtained powder was further calcinated, the changes in the morphology of the powders during calcination at 1000 ̊ C were reflected in the transition of spherically agglomerated needle-like nanoparticles of the multi-doped hydroxy-apatite powder to a spherical grained morphology. Macroporous bioceramic structures were obtained using the sponge replica method, green macroporous samples made of calcinated multi-doped powder, polyvinyl alcohol and water were sintered at 1.370°Ϲ and 1.430°Ϲ. X-ray diffraction analysis deter-mined that the presence of magnesium in the structure of hydroxyapatite favors the phase transformation of HAp into b-tricalcium-phosphate (b-TCP), which contributed to the formation of the biphasic HAp/b-TCP system during the calcination of the powders, but also during the sintering of macroporous beads. Examination of the antimicrobial activity of the obtained macroporous supports against E. coli showed a more effective degree of inhibition compared to S. aureus. A significant increase in the compressive strength of sintered macroporous scaffolds was obtained after the formation of coating based on 7.5% gelatin solution.

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“…Moreover, the addition of F − ions potentially arrests the formation of S. aureus. Dopants such as Cu, Zn, Mg, Ag added to HAp enhance antibacterial activity and decrease the toxic effects towards the human body cells [264][265][266][267]. For example, Mg-doped HAp shows better osteoblast cell adhesion than pure HAp [268].…”

Section: Calcium Phosphatesmentioning

confidence: 99%

Recent Advancements in Materials and Coatings for Biomedical Implants

Kirubaharan

Chandrasekar

Dasan

et al. 2022

Gels

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Metallic materials such as stainless steel (SS), titanium (Ti), magnesium (Mg) alloys, and cobalt-chromium (Co-Cr) alloys are widely used as biomaterials for implant applications. Metallic implants sometimes fail in surgeries due to inadequate biocompatibility, faster degradation rate (Mg-based alloys), inflammatory response, infections, inertness (SS, Ti, and Co-Cr alloys), lower corrosion resistance, elastic modulus mismatch, excessive wear, and shielding stress. Therefore, to address this problem, it is necessary to develop a method to improve the biofunctionalization of metallic implant surfaces by changing the materials’ surface and morphology without altering the mechanical properties of metallic implants. Among various methods, surface modification on metallic surfaces by applying coatings is an effective way to improve implant material performance. In this review, we discuss the recent developments in ceramics, polymers, and metallic materials used for implant applications. Their biocompatibility is also discussed. The recent trends in coatings for biomedical implants, applications, and their future directions were also discussed in detail.

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Research of Cu-Doped Hydroxyapatite Microbeads Fabricated by Pneumatic Extrusion Printing

Cited by 9 publications

References 26 publications

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

In Vitro Therapeutic Attributes of Luminescent Hydroxyapatite Nanoparticles in Codelivery Module

Processing and properties of scaffolds based on calcium phosphate doped with magnesium, copper and zinc-ions coated with gelatin

Recent Advancements in Materials and Coatings for Biomedical Implants

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