Research of Rearrangement Products of Gambogic Acid

Abstract

Gambogic acid derivatives possess potent anti-tumor activities against various cancer cell lines. In a search for new anti-tumor organic compounds, rearrangement reaction of gambogic acid was explored. After microwave irradiation under acidic condition, two rearrangement products were isolated and their structures were determined unambiguously by spectroscopic techniques. Both of them were screened for their cytotoxicities against A549, HCT116 and MDA-MB-231, and showed high inhibitory effects on the cell lines.