Research of the peculiarities of colloidal quantum dots of AgInS₂/ZnS and chitosan nanoparticles labeled with indocyanine green as the fluorescent labels for biomedical applications

Abstract

The research is devoted to the investigating of the possibility of using colloidal quantum dots, covered by various layers and nanoparticles of chitosan labelled with indocyanin green for fluorescence imaging in vitro and in vivo. Pure quantum dots and dots in the shell synthesized from 3-aminopropyltriethoxysilane and in the shell of albumin were investigated. Research using fluorescence Visualizer IVIS Lumina LT Series III (Perkin Elmer, USA) was conducted. The possibility of using quantum dots for in vitro diagnostics, and chitosan nanoparticles - in vitro and in vivo was presented.

Fluorescent Nanoagents for Biomedical Applications

“…There is a fundamental opportunity of using chitosan nanoparticles (NPC) as markers for in vitro and in vivo imaging in those areas of the body, where the vascular permeability changes dramatically. For this purpose, they are coated with fluorescent dyes, such as indocyanine green, fluorescein, or colloidal quantum dots [48,49].…”