Research of transport and deposition of aerosol in human airway replica

Lízal, František; Jedelský, Jan; Elcner, Jakub; Ďurdina, Lukáš; Halasová, Tereza; Mravec, Filip; Jícha, Miroslav

doi:10.1051/epjconf/20122502015

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…Three different particle sizes were used: 1, 4 and 8 μm. Plots of the velocity and turbulence profiles for full breathing cycle together with discussion of specific findings were already presented in our earlier paper (Jedelsky et al, 2010). Turbulence intensities at the steady and cyclic flows are compared in Table 1.…”

Section: Steady and Cyclic Flowsmentioning

confidence: 90%

“…The model covers airways from the throat to 3 rd -4 th generation of bronchi. Arrangement and description of our experimental device and the airway model is described in detail by Lizal et al, 2010. …”

Section: Experimental Apparatusmentioning

confidence: 99%

“…Mass median diameter of exhaled aerosol generated from surfactant film ranges between 0.7 and 2.8 μm depending on various factors (Schwartz et al, 2010). More aspects of the flow and deposition of the aerosols that are of our concern are closely reviewed in Lizal et al 2010.…”

Section: Introductionmentioning

confidence: 99%

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Study of cyclic and steady particle motion in a realistic human airway model using phase-Doppler anemometry

Jedelský

Lízal

Jícha

2012

EPJ Web of Conferences

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Section: Steady and Cyclic Flowsmentioning

confidence: 90%

Section: Experimental Apparatusmentioning

confidence: 99%

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Study of cyclic and steady particle motion in a realistic human airway model using phase-Doppler anemometry

Jedelský

Lízal

Jícha

2012

EPJ Web of Conferences

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“…However, due to the complexity of the flow in the respiratory tract, simplified models have been developed to understand the characteristics of the flow. A consistent simplification in respiratory fluid dynamics research is the omission of the undulations introduced by the cartilage rings, that is, the use of smooth walls [ 1 , 3 , 4 , 9 , 10 , 22 , 24 , 32 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of cartilaginous rings in tracheal flow with stenosis

et al. 2023

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Background In respiratory fluid dynamics research, it is typically assumed that the wall of the trachea is smooth. However, the trachea is structurally supported by a series of cartilaginous rings that create undulations on the wall surface, which introduce perturbations into the flow. Even though many studies use realistic Computer Tomography (CT) scan data to capture the complex geometry of the respiratory system, its limited spatial resolution does not resolve small features, including those introduced by the cartilaginous rings. Results Here we present an experimental comparison of two simplified trachea models with Grade II stenosis (70% blockage), one with smooth walls and second with cartilaginous rings. The use a unique refractive index-matching method provides unprecedented optical access and allowed us to perform non-intrusive velocity field measurements close to the wall (e.g., Particle Image Velocimetry (PIV)). Measurements were performed in a flow regime comparable to a resting breathing state (Reynolds number ReD = 3350). The cartilaginous rings induce velocity fluctuations in the downstream flow, enhancing the near-wall transport of momentum flux and thus reducing flow separation in the downstream flow. The maximum upstream velocity in the recirculation region is reduced by 38%, resulting in a much weaker recirculation zone— a direct consequence of the cartilaginous rings. Conclusions These results highlight the importance of the cartilaginous rings in respiratory flow studies and the mechanism to reduce flow separation in trachea stenosis.

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Flow Recirculation in Cartilaginous Ring Cavities of Human Trachea Model

Evans

Castillo

2018

Journal of Aerosol Medicine and Pulmonary Drug Delivery

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The detection of recirculation zones in the cartilage ring cavities sheds light on the particle deposition mechanism and helps explain results from previous studies that have observed an enhancement of particle deposition in models with cartilage rings. These results bring to light the importance of including cartilage rings in experimental, numerical, and theoretical models to better understand particle deposition in the trachea and bronchi. In addition, the results provide scientists and medical staff with new insights for improving drug delivery.

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Research of transport and deposition of aerosol in human airway replica

Abstract: Growing concern about knowledge of aerosol transport in human lungs

Cited by 3 publications

References 21 publications

Study of cyclic and steady particle motion in a realistic human airway model using phase-Doppler anemometry

Study of cyclic and steady particle motion in a realistic human airway model using phase-Doppler anemometry

Effect of cartilaginous rings in tracheal flow with stenosis

Flow Recirculation in Cartilaginous Ring Cavities of Human Trachea Model

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