The choice of the parameters of the secondary sound source which contain the number、 position and strength is a key part in the design of active noise control system of power transformer. Countering the practical applications environment of noise control of transformer, acoustic radiation model in half-free space is established. After selecting the sum of the squared sound pressures of the observation points as the objective function, the genetic algorithm is used to optimize the position of secondary sound source and the optimal source intensity can be resolved by using the analytical method. By single frequency experiment, the availability of applying optimization scheme of the secondary sound sources to practical transformer noise control is verified.