Described is an analysis of the frequency response fluctuations of the multimode fiber impact on the Orthogonal frequency division multiplexing (OFDM) transmission. There is provided theory, numerical calculations and measurements. We analyze extreme and moderate frequency response fluctuation cases. Orthogonal frequency division multiplexing transmission is possible even in pass band when the spatial light filtration is moderate. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:845–849, 2013; View this article online at wileyonlinelibrary.com. DOI: 10.1002/mop.27402