PurposeThis paper takes the manufacturing cluster supply chain as the research object and explores the evaluation and enhancement strategy of manufacturing cluster supply chain synergy. The purpose of this study was to (1) analyze the mechanism of manufacturing cluster supply chain synergy; (2) construct manufacturing cluster supply chain synergy evaluation model; (3) algorithm realization of manufacturing cluster supply chain synergy evaluation and (4) propose manufacturing cluster-based supply chain synergy enhancement strategy.Design/methodology/approachBreaking through the limitations of traditional manufacturing cluster supply chain synergy evaluation, we take horizontal synergy and vertical synergy as coupled synergy subsystems, use the complex system synergy model to explore the horizontal synergy between core enterprises and cluster enterprises and the vertical synergy of supply chain enterprises and use the coupling coordination model to construct the coupled synergy evaluation model of manufacturing cluster supply chain, which is an innovation of the evaluation perspective of previous cluster supply chain synergy and also an enrichment and supplementation of the evaluation methodology. This is not only the innovation of the evaluation perspective but also the enrichment and supplementation of the evaluation method.FindingsUsing Python software to conduct empirical analysis on the evaluation model, the research shows that the horizontal and vertical synergies of the manufacturing cluster supply chain interact with each other and jointly affect the coupling synergy. On this basis, targeted strategies are proposed to enhance the synergy of the manufacturing cluster supply chain.Research limitations/implicationsThis study takes manufacturers, suppliers and sellers in the three-level supply chain as the research object and does not consider the synergistic evaluation between distributors and consumers in the supply chain, which can be further explored in this direction in the future.Practical implicationsAdvanced manufacturing clusters, as the main force of manufacturing development, and the synergistic development of supply chain are one of the important driving forces for the high-quality development of China’s manufacturing industry. As a new type of network organization coupling industrial clusters and supply chains, cluster supply chain is conducive not only to improving the competitiveness of cluster supply chains but also to upgrading cluster supply chains through horizontal synergy within the cluster and vertical synergy in the supply chain.Social implicationsResearch can help accelerate the transformation and upgrading of clustered supply chains in the manufacturing industry, promote high-quality development of the manufacturing industry and accelerate the rise of the global value chain position of the manufacturing industry.Originality/value(1) Innovation of research perspective. Starting from two perspectives of horizontal synergy and vertical synergy, we take a core enterprise in the cluster supply chain as the starting point, horizontally explore the main enterprises of the cluster as the research object of horizontal synergy, vertically explore the upstream and downstream enterprises of the supply chain as the research object of vertical synergy and explore the coupling synergy of cluster supply chain as two subsystems, which provides new perspectives of evaluation of the degree of synergy and synergy evaluation. (2) Innovation of research content. Nine manufacturing clusters are selected as research samples, and through data collection and model analysis, it is verified that the evaluation model and implementation algorithm designed in this paper have strong practicability, which not only provides methodological reference for the evaluation of manufacturing cluster-type supply chain synergy but also reduces the loss caused by the instability of clusters and supply chains and then provides a theoretical basis for improving the overall performance of cluster-type supply chains.