Research on Establishment of Abnormal Phlegmatic Syndrome with Premature Ovarian Failure Rat Model and Effects of Balgham Munziq Treatment

Abstract

This study aimed to establish and explore the biological basis of abnormal phlegmatic syndrome with premature ovarian failure (POF) model in rats based on the Uighur medicine (UM) in the first place and investigate the effects of unique herbal medicine, Balgham Munziq (BMq). Mature female Wistar rats were fed with spinach and coriander in cold and humid condition for approximately 20 weeks until abnormal phlegmatic syndrome (APS) model was established. When APS model was confirmed by Uighur medical experts, APS with POF disease rats were subdivided into APS with POF disease model group and APS with POF disease treated with BMq group; the rest of them were subdivided into APS model group and APS treated with BMq group. The results show that biological characteristics of animals in the course of modeling period were in accordance with clinical features of abnormal phlegmatic syndrome (APS) in Uighur medicine. Herbal medicine BMq not only reverted reproductive hormone levels disorders but also improved the function of hypothalamic-pituitary-ovarian axis and regulated secretion of monoamine neurotransmitters. APS is most likely to cause pathological changes of hypothalamic-pituitary-ovarian axis and lead to the occurrence of POF and BMq is effective in the treatment of APS with POF disease.

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“…Maturing and removing abnormal body fluids can correct the abnormal temperament, promote the formation of normal body fluid and restore the body force of nature 16 . "Monzej-e-balgham" has been used in Iranian traditional medicine to provide a basis for healing and treatment of various diseases caused with wet and cold natures (diseases occurring due to phlegm accumulation) such as diseases with symptoms which are today known as Alzheimer's disease 6 , stroke 7 , coronary heart disease 8 , overweight 9 , vitiligo 3 and premature ovarian failure (POF) 4 .…”

“…ITM believes in regulation or elimination of the waste humor to cure diseases with "Monzej" es 3 . "Monzej"es are applied for treatment to mature and eliminate the abnormal humor, correcting the abnormal temperament than to promote the formation of normal humor, restore the function of organs and the body natural force 3,4 .…”

“…"Monzej-e-balgham", a traditional herbal medicine prescription, has been widely used in Iranian traditional medicine for a long time. It can eliminate the abnormal "Balgham" humor from the body and restore the balance between all humor 4,5 . "Monzej-e-balgham" has been playing an effective role in various diseases caused by cold and wet qualities (diseases occurring due to phlegm accumulation) such as Alzheimer's disease 6 , stroke 7 , coronary heart disease 8 , overweight 9 , vitiligo 3 and premature ovarian failure (POF) 4 in human body according to modern research.…”

“…It can eliminate the abnormal "Balgham" humor from the body and restore the balance between all humor 4,5 . "Monzej-e-balgham" has been playing an effective role in various diseases caused by cold and wet qualities (diseases occurring due to phlegm accumulation) such as Alzheimer's disease 6 , stroke 7 , coronary heart disease 8 , overweight 9 , vitiligo 3 and premature ovarian failure (POF) 4 in human body according to modern research. Different formulations of "Monzej-e-balgham" could be found in ITM textbooks, among diverse prescriptions, a combination of roots of Glycyrrhiza glabra L., liquorice, (Paplionaceae), fruits of Foeniculum vulgare Mill., fennel, (Apiaceae), aerial parts of Adiantum capillus-veneris L., maidenhair fern, (Polypodiaceae), fruits of Vitis venifera L., large raisins, (Vitaceae), fruits of Ficus carica L., fig, (Moraceae), flowers of Rosa damascene Herrm., damask rose, (Rosaceae) and seeds of Onopordum acanthium L., cotton thistle, (Asteraceae) was selected 10 .…”

Polyherbal tablet based on Iranian traditional medicine

“…The present study tried to formulate one traditional drug form, namely "Monzej-ebalgham". The medications that maturate phlegm (balgham) are widely used in ITM for the treatment of different diseases such as stroke [7,8], hemiplegia due to ischaemic stroke [9], cardiovascular disease risk factors such as metabolic abnormalities like abdominal obesity, high cholesterol, high blood pressure and high blood glucose [10], overweight [11], atherosclerosis [12], premature ovarian failure (POF) [13], impotence [14], bronchitis [15] and vitiligo [16,17] according to modern studies. Various formulations of "Monzej-e-balgham" could be found in important traditional pharmacopeia and the types of plants have been proposed in different medical prescriptions.…”