A structure does not reach a stable state during the construction process, and hence its structural reliability is low. In order to ensure the safety of the construction process and final structural quality, it is necessary to analyze the safety and structural mechanical properties of large-span space steel structures during the construction process. Based on the engineering background of the polyline symmetrical large-span steel structure construction process, this research established a finite element model of the large-span steel structure on an ANSYS platform. The correctness of the model was verified by comparing the measured frequency of the large-span steel structure with the frequency calculated in the finite element model. Based on the life-death element method, the internal force and deformation response characteristics of the large-span steel structure in the construction process were analyzed, and the different effects of the on-time completion and step-by-step construction on the performance of the broken-line large-span steel structure were compared and analyzed. The study found that the long-span steel truss structure is more sensitive to the construction process, and the final forming state is greatly affected by the construction process. The construction sequence is different, and the structure process and size and distribution of the final stress and deformation are also different. The analysis result of the construction process is closer to that of the actual project. Therefore, appropriate construction paths should be used in the construction process to reduce the impact of path effects on structural performance. It is recommended to pay more attention to the displacement and stress response of the truss when it encounters similar a symmetrical long-span steel structure truss in-place of the forming construction.