The aerodynamic characteristics of a multispan suspension bridge differ from those of a two-span suspension bridge. In this study we investigated the nonlinear aerodynamic characteristics of the Maanshan Bridge under nonstationary flow using combination quasi-3D finite element (FE) bridge models of 2D nonlinear aerodynamic force models and 3D nonlinear FE bridge models. The developed model predictions were validated by wind tunnel tests involving a 2D sectional stiffness model and 3D full-bridge aeroelastic model. Results showed that the developed model could potentially describe the nonlinear and unsteady aerodynamic effects on the bridge. Furthermore, the flutter behavior of the Maanshan Bridge under uniform flow changed from the stable limit cycle of soft flutter to unstable limit cycle with the disconnection of two hangers at the 1/2L of the right main span, while the flutter behavior of the bridge under turbulence flow could be defined as the fracture failure of the hangers from the 1/2L of the left main span.