Research on heterocyclic compounds. XXXII. Synthesis and cyclooxygenase-independent antiinflammatory and analgesic activity of imidazo[1,2-a]pyrimidine derivatives

Ionic Liquids-Prompted Synthesis of Biologically Relevant Five- and Six-Membered Heterocyclic Skeletons

“…Highly ordered mesoporous functional organosilica incorporating chiral camphorsulfonamide entities were synthesized by hydrolysis-polycondensation involving chiral imidazolium precursors and tetraethoxysilane [59]. Imidazolium salts with a cyclophane-type planar chirality (14)(15)(16)(17)(18) represent a novel class of CILs with a well-defined three dimensional dissymmetric structure are sufficiently stable (Figure 9) [61]. Imidazolium salts with a cyclophane-type planar chirality (14)(15)(16)(17)(18) represent a novel class of CILs with a well-defined three dimensional dissymmetric structure are sufficiently stable (Figure 9) [61].…”

Heterocycles 48. Synthesis, Characterization and Biological Evaluation of Imidazo[2,1-b][1,3,4]Thiadiazole Derivatives as Anti-Inflammatory Agents

“…In recent years, imidazo[2,1- b ][1,3,4]thiadiazole derivatives have been intensively studied because of their wide range of biological activities. The imidazo[2,1- b ][1,3,4]thiadiazole scaffold makes up the core structure of pharmacological active molecules possessing antimicrobial [ 8 , 9 ], anticonvulsant [ 10 , 11 ], diuretic [ 12 ], anticancer [ 13 , 14 , 15 ], antitubercular [ 16 ], analgesic [ 17 ] and anti-inflammatory [ 18 , 19 ] properties.…”

Design, Network Analysis and In Silico Modeling of Biologically Significant 4-(substituted benzyl)-2-Amino-6-HydroxyPyrimidine-5-Carboxamide Nanoparticles

“…The literature review revels that, the uniqueness and importance of pyrimidines and fused pyrimidines. They are widely used as key building blocks for pharmaceutical agents and it's known to exhibit pharmacological activities like analgesic, anti-inflammatory [1][2][3][4][5][6][7][8], antitumor [9], antifolate [10], antihistaminic [11], antibacterial [12], antiviral [13], antituberculosis [14], Design, Network Analysis and In Silico Modeling of Biologically Significant 4-(substituted benzyl)-2-Amino-6-HydroxyPyrimidine-5-Carboxamide Nanoparticles antihypertensive [15], hypoglycaemic [16], anticonvulsive [17], PDE4 inhibitor [18]. Led by above facts on pyrimidine chemistry, the compound 4-(4-hydroxy benzyl)-2-amino-6-hydroxypyrimidine- 5-carboxamide was chosen for insilico modeling with identified drug target AGT, TNF, F2 and BCL2L1 (PDB ID: 2WXW, 4G3Y, 4NZQ, 1R2D, 1PXE and 1CQE) for wound healing, anti-inflammatory and pain management.…”