Research on heterocyclic compounds. XXXIV. Synthesis and SAR study of some imidazo[2,1-b]thiazole carboxylic and acetic acids with antiinflammatory and analgesic activities

6-(4-Bromophenyl)-2-(4-fluorobenzyl)imidazo[2,1-b][1,3,4]thiadiazole

“…NSB is thankful to the University Grants Commission (UGC), India, for financial assistance and the Department of Science and Technology, (DST), India, for the data-collection facility under the IRHPA-DST program. antimicrobial, anti-inflammatory, antipyretic, analgesic properties and many other activities of therapeutic significance (Palagiano et al, 1995). Moreover, the presence of fluoro substituent in a molecule enhances biological activity.…”

“…For general background to imidazothiadiazole derivatives, see: Palagiano et al (1995). Accumulation of fluorine on carbon leads to increased oxidative and thermal stability, see: Strunecka et al (2004); Park et al (2001).…”

A facile and convenient synthesis of novel imidazo[1,2-b] isoxazoles and their Mannich bases as potential biodynamic agents

“…Based on the bio activities of imidazole and isoxazole ring systems, we proposed to construct a system that combine these bio-labile rings together in a single molecular frame work. The synthesis of imidazo [2,1-b]thiazoles are reported earlier and these compounds showed promising biological activity [20,21]. Based on these reports, and as a sequel to our work on the synthesis of fused isoxazoles [22], we herein, wish to report the synthesis of novel imidazo [1,2-b]isoxazoles and their Mannich bases as potential biodynamic agents.…”

Synthesis of some 3,4-disubstituted-6,7-dihydro-imidazo[2,1-b][1,3]thiazole and 3,4-disubstituted-7,8-dihydro-6H-imidazo[2,1-b][1,3]thiazine derivatives and evaluation of their cytotoxicities against F2408 and 5RP7 cells

“…These activities range from analgesic-anti-inflammatory (Palagiano et al, 1995); antifungal (Ç apan et al, 1999), antibacterial (Gadad et al, 2000), antimicrobial (Ur et al, 2004), antimycobacterial (Cesur et al, 1994), antituberculosis (Ulusoy, 2002), antisecretory (Andreani et al, 2000), cardiotonic (Andreani et al, 1996), cytotoxic (Terasawa et al, 2001;Gürsoy and Ulusoy-Güzeldemirci, 2007), antitumor (Andreani et al, 2005a) activities to inhibition on 5-lipoxygenase (Bender and Gleason, 1992), mitochondrial nicotinamide adenine dinucleotide dehydrogenase (NADH) (Andreani et al, 1999), acetyl cholinesterase (Andreani et al, 2005b), and human constitutive androstane receptor (CAR) (Auerbach et al, 2005).…”