The prime purpose of the proposed study is to construct a novel predictive scheme for assisting in the prognosis of criticality using the MIMIC-III dataset. With the adoption of various analytics and advanced computing in the healthcare system, there is an increasing trend toward developing an effective prognostication mechanism. Predictive-based modeling is the best alternative to work in this direction. This paper discusses various scientific contributions using desk research methodology towards the Medical Information Mart for Intensive Care (MIMIC-III). This open-access dataset is meant to help predict patient trajectories for various purposes ranging from mortality forecasting to treatment planning. With a dominant machine learning approach in this perspective, there is a need to discover the effectiveness of existing predictive methods. The resultant outcome of this paper offers an inclusive discussion about various available predictive schemes and clinical diagnoses using MIMIC-III in order to contribute toward better information associated with its strengths and weaknesses. Therefore, the paper provides a clear visualization of existing schemes for clinical diagnosis using a systematic review approach.