The performance of heat exchangers in the pressurized water test loop is a critical factor in ensuring the achievement of irradiation parameters for fuel assemblies and the safety of experimental operations. The effect of the heat exchange area margin on the heat exchangers in the pressurized water test loop for the fuel assembly during the steady-state irradiation is analyzed. Additionally, optimization methods for determining the margin of heat exchange area and corresponding design strategies are further investigated. It shows that the effect of the heat exchange area margin on the heat exchange power is less affected by the inlet temperature of the primary water and is primarily influenced by the flow rate of the primary water. A decrease in the flow rate of the primary water reduces the compensatory effect of the cooling section on power and enhances the weakening effect of the regeneration section on power. Meanwhile, the correspondence between the margin of the regeneration section and the cooling section, established based on design conditions, can be applicable when there are changes in the inlet temperature of the primary water, but it is not suitable when there are changes in the flow rate of the primary water. When the flow rate of the primary water decreases, the cooling section margin required to compensate for the decrease in power caused by the regeneration section margin will increase significantly. In addition, short-circuiting the heat exchange tubes in the regeneration section can effectively enhance the heat transfer capability. Furthermore, setting the heat exchange area margins of the regeneration and cooling sections to zero can serve as a termination condition for iterative calculations in the verification of regenerative heat exchangers under off-design conditions.