This research aimed to analyze the possibility of installing an ultrasonic emitter in an already manufactured car and to prove the possibility of cleaning the exhaust gases of an internal combustion engine through the action of an ultrasonic wave due to coagulation and examining the optimal regimes of its work. The existing theoretical solution to describe the proposed process was analyzed. A Mercedes-Benz M-Class ML 270 CDI MT car with the OM 612 DE 27 LA Diesel engine was used for the experiment. An ultrasound generator and an ultrasound emitter were connected to the muffler. The stand was connected to the car via the inlet with a rubber hose that directs the exhaust gases out of the car. The crankshaft speed of the engine was changed in the range of 750 to 1250 rpm, which corresponds to urban conditions when cars are moving in heavy traffic jams. The content of CH, CO, CO2, and O2 in the exhaust gas of the vehicle was determined as a function of the crankshaft speed without ultrasonic exposure and with ultrasonic exposure at an ultrasound frequency of 25, 28, and 40 kHz. The results of the experiment showed that the introduction of an ultrasonic emitter into the muffler reduced the smoke content of the gas, increased the oxygen content, and reduced the amount of carbon dioxide in the exhaust gases. With an increase in the ratio between the ultrasonic frequency and the angular velocity of the engine crankshaft (f/ω), the smoke content of the gas also decreased. At the maximum values of ultrasonic frequency and angular velocity of the engine crankshaft selected in the experimental studies, the minimum value of the ratio of gas smoke indicators was achieved, and the degree of purification was 10–13%. Such results correspond to the condition of optimal operation of the ultrasonic muffler, where the ratio of gas to smoke values should tend to a minimum. These results confirm the potential of using ultrasound as a method for cleaning exhaust gases and underline the need for further research in this area.