Research on Preparation and Biological Properties of Dense Hydroxyapatite Spheres

Abstract

By using carboxy methyl chitosan (CMCS) and gelatin (Gel) as adhesive, the nano–HA slurry which was fabricated via a precipitation process as the raw material, dense HA spheres with a uniform size distribution and good geometry were prepared successfully by means of Sol-Gel method. Dense HA spheres with a porosity of 4.7%±0.6% have a higher compressive strength (8.9±0.4) MPa than that of porous HA spheres (7.9±0.2) MPa with a porosity of 16.4%±0.5% (particles with diameter of 0.5 mm). The results of biomimetic mineralization and cell culture show that dense HA spheres have an excellent biological property

Fabrication and characterization of novel porous titanium microspheres for biomedical applications

“…During the compression test, a load was applied until densification of the porous samples started to occur. The compressive strength (MPa) of each specimen was calculated according to P = 4F/πD 2 [21], where F was the fracture load in N and D the diameter of the specimen in mm.…”