A canned nuclear coolant pump is used in an advanced third-generation pressurized water reactor. Impeller is a key component of a canned nuclear coolant pump. Usually, the blade is installed between the hub and the shroud as an entire part. The blade is divided into two parts and is staggered in the circumferential direction is an approach of blade design. To understand the effects of staggered blades on a canned nuclear coolant pump, this article numerically investigated different types of staggering. The validity of the numerical simulation was confirmed by comparing the numerical and experimental results. The performance change of a canned nuclear coolant pump with staggered blades was acquired. Hydraulic performance curves, axial force curves, static pressure distributions at the impeller outlet, and static pressure pulsations were performed to investigate the performance changes caused by the staggered blades. The results show that the staggered blade has an important influence on the performance of canned nuclear coolant pumps. A staggered blade does not improve hydraulic performance but does improve the axial force and pressure pulsation. Specifically, the staggered blades can significantly reduce the pressure pulsation amplitude on the impeller pass frequency.