With the continuous development of network technology, network technology has been applied to various fields of social life and production. The development of Library and information industry is advancing with the progress of technology and has brought about great changes. How to face the challenge of the progress of network technology for Library and information science, and how to promote the reform and innovation of Library and information science is an important problem at present. This paper aims to study the challenges faced by library and Information Science in the era of network, and look forward to the future reform and innovation direction and path of Library and information science through the current situation. In this paper, qualitative and quantitative research methods combined with CO word analysis are used to sort out the interdisciplinary research topics of Library and information science, as well as the changes and comparison of Library and information science research methods in the era of network, so as to get the development trend and direction of Library and Information Science in China. Research and analysis show that the main research of Library and information science focuses on "computer and computer application". With the continuous progress of network technology, there are more and more network technologies involved in Library and information institutions, which will produce more and more research topics. At the same time, the research methods of Library and Information Science in China are also out of date. Only by applying computer technology Only by applying it to the research and enriching the existing researchers to construct the network of information resources, can the data statistics and analysis be carried out with the highest efficiency, so as to realize the positive promotion for the discipline and other disciplines. In the network era, the future development of Library and information science requires us to make steady progress and comply with the new requirements and changes of the network era, so as to make the development of Library and information science more complete and adapt to the higher requirements of the network era.