Constructing a unified Live-Virtual-Constructive (LVC) integrated simulation environment has always been a major goal in the modeling and simulation (M&S) field, and ensuring the time-space consistency is the foundation of its construction. That is, the inconsistency of time and space expression between integrated subsystems must be solved to achieve accurate and effective information interaction. To this end, this paper analyzes the specific causes of time-space inconsistency of LVC system, and gives the overall solution and the corresponding strategies or algorithms involved, including clock synchronization strategy, space coordinate conversion algorithm, time description conversion algorithm, dead reckoning (DR) algorithm and event causality control method. The relevant research has been verified in the integrated simulation system of missile attacking surface targets, and can provide technical support for the construction of large-scale LVC system.