To solve the problems such as hand measurement, experience design and not consider area utilization of pallet, the paper researched the flow and method of size design of corrugated box when it was regularly placed in the standard pallet. The paper designed a new method to calculate the size of corrugated box which was “from outside to inside, and then from inside to outside” through optimize the way of arrangement and the number of product in which the object of study was assumed by taking product as quasi-square and cylinder and outer packaging container as corrugated box. Both the standard pallet sizes and product dimensions were considered, and it provide theoretical basis for preparing related computer software. At the same time, it ensure pallet utilization and volume rate of corrugated box, reduce transport cost farthest and realize the goal of packaging reduction.