Introduction. The article discusses the potential of pedagogical universities in solving the problem of career guidance in the country. The current state of career guidance is described, the reasons for its low efficiency, as well as the role of the initial stage of schooling, as the basis for the formation of professional skills are assessed.Materials and Methods. The research was based on publications, monographs, dissertations of domestic and foreign scientists in the field of career guidance, a comparative analysis of the data of sociological surveys was carried out, methods of analysis, synthesis and modeling of the socio-pedagogical space were used.Results. It is established that the ineffective organization of career guidance leads to errors in choosing a profession, which is an unfavorable factor not only for personal growth, but also harms the country's economy. This dictates the need to develop a new direction of activity in the conditions of pedagogical universities, which, having the necessary personnel and production potential, can become regional career guidance centers, providing methodological guidance and coordination activities, accompanying and supporting career guidance work of schools, implementing comprehensive career guidance diagnostics programs, as well as training programs career counseling specialists (career counseling advisors). These specialists, carrying out qualified systemic activities in various educational institutions, will be able to work in the information, educational, diagnostic, consultative, intermediary and other areas. The authors prove the need for a system-activity approach to career guidance, the elements of which should be interconnected and led.Discussion and Conclusion. The article proposes a new model for organizing career guidance work, proves the need for a system-activity approach, based on the continuity of all levels of education. The main provisions of the article can become the basis of relevant pedagogically sound career guidance projects that take into account the socio-economic interests of the state and the needs of subjects of career guidance choices.