Research on the Anti-tumor Activity of Novel Histone Deacetylase Inhibitors based on 3D QSAR Model
Liqiang Meng,
Yanhong Ou Yang,
Jianxin Yao
et al.
Abstract:Background
Histone deacetylases (HDACs) pertain to the category of Zn2+ or nicotinamide adenine dinucleotide (NAD+)-dependent proteolytic enzymes. While the antitumor effect of HDAC inhibitors alone has been demonstrated and the effect of HDAC inhibitors on solid tumors is not ideal, which considerably limits their clinical use. Therefore, the search for novel HDAC inhibitors equipped with specific inhibitors is extremely urgent and necessary.
Methods
3D-QSAR was employed to investigate insights into the cru… Show more
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