In the development and operation of modern enterprises, human resource management is an important part of enterprise management, so the level of enterprise human resource management will bring far-reaching impact to the enterprise operation and development, which requires enterprises to pay great attention to human resource management. The traditional human resource management mode of enterprises has obvious limitations, which is difficult to guarantee the effect of enterprise management and control, and the lack of reasonable and perfect incentive mode may aggravate the loss of enterprise personnel. In order to effectively avoid such situations, strengthening the application of flexible management in human resource management can usually achieve excellent results. Based on this, this paper mainly focuses on the application of flexible management in enterprise human resource management, in order to provide reference for relevant personnel.