Research on the Association Between Obstructive Sleep Apnea Hypopnea Syndrome Complicated With Coronary Heart Disease and Inflammatory Factors, Glycolipid Metabolism, Obesity, and Insulin Resistance

Abstract

The aim of this study is to explore the association between obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with coronary heart disease (CHD) and inflammatory factors, glycolipid metabolism, obesity, and insulin resistance. A total of 400 patients diagnosed with OSAHS who underwent polysomnography (PSG) monitoring in the Sleep Diagnosis and Treatment Center of Beijing Luhe Hospital from March 2015 to September 2018 were selected and divided into the OSAHS group (n = 200) and the OSAHS + CHD group (n = 200) according to disease condition. The questionnaire survey was conducted, the somatology indexes were measured, and the PSG, insulin, glycolipid metabolism parameters, and serum inflammatory factors were detected. Body weight, body mass index, waist circumference, and Epworth sleepiness scale (ESS) score were all significantly increased in the OSAHS + CHD group compared with those in the OSAHS group (p < 0.05). The microarousal index (MAI), apnea hypopnea index (AHI), cumulative percentage of time spent at oxygen saturation below 90% (CT90%), oxygen desaturation index (ODI), lowest oxygen saturation (LSaO2), total apnea time (TAT), and mean oxygen saturation (MSaO2) had statistically significant differences between the OSAHS + CHD group and the OSAHS group (p < 0.05). According to the Spearman correlation analysis of AHI, LSaO2, MSaO2, CT90%, ODI, and MAI with HOMA-IR in both groups, MAI, AHI, CT90%, and ODI were positively correlated with HOMA-IR (r > 0), while LSaO2 and MSaO2 were negatively correlated with HOMA-IR (r < 0). Compared with the OSAHS group, the OSAHS + CHD group had an obviously increased level of triglyceride (TG) (p < 0.05), and obviously increased levels of serum inflammatory factors C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interferon-γ (IFN-γ) (p < 0.05). The occurrence of OSAHS complicated with CHD is related to inflammatory factors, glycolipid metabolism, obesity rate, and HOMA-IR.

Predictive Modeling of Resistant Hypertension Risk: Incorporating the TyG Index and Clinical Factors

“…Studies have also confirmed a close correlation between fasting blood glucose levels and blood pressure levels and identified it as an independent risk factor for elevated blood pressure [34]. Furthermore, we found that patient age, AHI score, uric acid levels, and fasting blood glucose levels all influence IR [35][36][37][38][39]. This may explain why IR has the highest HR value among quantifiable indicators in independent risk factors while also suggesting that IR is a major cause for the progression from high blood pressure to RH.…”

Unintentional fall mortality by place, sex, and age group among older Chinese adults, 2010–21

“…High circulating lipids, particularly low-density lipoprotein cholesterol, deposited in the coronary arterial wall can cause endothelial cell damage and inflammation, promote plaque formation and rupture, and lead to myocardial ischemia and even necrosis [44]. Previous studies have also shown that poor sleep or pro-oxidant dietary and lifestyle behaviours, including sleep apnea, short sleep duration, unhealthy diet (low in fiber and high in meat), and low PA may lead to CHD caused by abnormal glycolipid metabolism, endothelial dysfunction, oxidative stress, and inflammation [45][46][47][48]. Therefore, sleep behaviours, OBS, and hyperlipidaemia may have a synergistic effect on CHD through common pathways, which has also been indicated in our findings that the suggestive interaction correlation was found between the combined unhealthy sleep patterns, pro-oxidant OBS, and hyperlipidaemia.…”