In order to analyze the backscattering characteristics of pulsed laser fuze in typical smoke, copper powder and iron powder with a particle size range of 3~15 μm were selected, the detection model of pulsed laser fuzes in typical smoke was established based on Mie scattering theory and Monte Carlo method. The pulsed laser fuze is simulated to scatter echoes behind smoke curtains with different detection distances, different smoke screen thicknesses and different emitting laser pulse widths, and the echo intensities of copper powder smoke screens and iron powder smoke screens under the same smoke screen conditions are compared. The results show that the normalized echo intensity of copper powder smoke screen and iron powder smoke screen is negatively correlated with the detection distance. It is positively correlated with smoke screen thickness and emitted laser pulse width. In addition, under the same smoke screen environmental conditions, the echo intensity of the iron powder smoke screen is significantly stronger than that of the copper powder smoke screen, which can be explained that compared with the iron powder, copper powder is more suitable for use as a smoke generator material, the result can provide support for the anti-smoke interference of the laser fuze.