2014
DOI: 10.4028/www.scientific.net/amm.540.343
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Research on the Chemical Materials of Inosine Di- and Triphosphate

Abstract: Inosine 5′-triphosphate (ITP) and 5′-diphosphates (IDP) were efficiently synthesized. Phosphitylation, acid-catalyzed hydrolysis, and oxidative coupling with piperidine afforded inosine phosphoropiperidate benzyl ester intermediate in good yield. Inosine polyphosphates were obtained by coupling the deprotected phosphoropiperidate with 4,5-dicyanoimidazole (DCI) as the activator.

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