Based on the discrete phase model (DPM), solid–liquid two-phase flow calculation, particle settling theory and MATLAB image processing technology, the influence of the installation position of submersible pumps on the deposition characteristics in a cylinder-type prefabricated pumping station was studied, and two performance indices, the deposition rate and area ratio of the easy deposition region were proposed. The results show that the area ratio and deposition rate of the easy deposition region increase as the suspension height increases. The discharge effect is best when the suspension height is 0.1H0, however, at this time the inlet bias of the pump is larger, which is not conducive to the smooth operation of submersible pumps. The area ratio and deposition rate of the easy deposition region gradually increase with the increase in the interval of the pumps. As the center distance increases, the area ratio and deposition rate of the easy deposition region basically decreases first and then increases, and reach the minimum at 0.1R and 0R, respectively.