In this paper, a space-driven two-stage spur gear system is taken as the research object, and a 10 DOF dynamic model is established. Considering the high load characteristics of the space drive system and the time-varying stiffness and tooth clearance of the gear system, a nonlinear dynamic response analysis was performed. The characteristics of the vibration acceleration, shock and transmission error of the gear system are studied in this paper. This paper analyzes the relationship between backlash and return difference, and derives the theoretical formula between the two. The time-varying stiffness was corrected to make the theoretical model closer to reality. The research in this paper enriches the study on space drive systems and high load gear systems.