Research on the establishment of chronic stress‐induced premature ovarian failure the rat model and effects of Chinese medicine Muniziqi treatment

Keremu, Abulizi; Yaoliwasi, Aziguli; Tuerhong, Mayire; Kadeer, Nafeisha; Heyi,; Yiming, Adilijiang; Yilike, Xiamixinuer

doi:10.1002/mrd.23092

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…Xie et al reported that the Huyang Yangkun formula repaired dysfunctions in POI rats through the Hippo-JAK2/STAT3 pathway [ 24 ]. Keremu et al reported that TCM Muniziqi improved the function of the hypothalamus-pituitary-ovarian axis in POF rats [ 25 ]. TCM could treat POF that is caused by apoptosis or immunosuppression [ 26 , 27 ].…”

Section: Application Of Traditional Chinese Medicine In Pofmentioning

confidence: 99%

Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure

Xiao

Wei³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Premature ovarian failure (POF) is characterized by hormonal disorders, amenorrhea, and premature loss of fertility potential in women of reproductive age. Several studies have been conducted on the effectiveness of traditional Chinese medicine (TCM) in treating POF. TCM relied primarily on apoptosis, immunity, and aging to treat POF based on the studies of domestic and foreign literature. Zuogui pills inhibited mitochondrial-dependent apoptosis in the treatment of POF. Huyang Yangkun formula regulated the downstream of the Bcl-2 family to resist apoptosis through the aquaporin-1 protein. Modified Bazhen decoction regulated apoptosis in POF by regulating X-linked inhibitors of apoptosis protein. Bushen Tianjing recipe was effective in treating POF by promoting angiogenesis and preventing apoptosis. As for immunity, Bushen Jianpi prescription and Er-Xian decoction cured autoimmunity POF models and increased follicular development-related protein expression. Bushen Huoxue Tang improved ovarian function and reduced ovarian inflammation by regulating the Nrf2/Keap1 signaling pathway and T lymphocytes. Taohong Siwu decoction promoted the proliferation and differentiation of granulosa cells of POF mice by regulating the TGF-β1/Smads signaling pathway. In addition, ginsenoside Rg1 and Jiajian Guisheng formula treated POF by regulating cell aging-related mechanisms. Si Wu Tang treated POF by activating the angiogenesis-related proteins. The goal of this review is to serve as a reference for in-depth research into the treatment of POF with TCM and provide inspiration for new diagnostic methods and treatment options.

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Section: Application Of Traditional Chinese Medicine In Pofmentioning

confidence: 99%

Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure

Xiao

Wei³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In traditional Chinese medicine (TCM), most doctors agree that the main pathogenesis of POI is kidney deficiency and blood stasis, so BHD is also extensively applied in treating POI [24]. More and more studies have shown that chronic stress is an important cause of decreased ovarian function and reproductive endocrine disorders [25][26][27], and BHD can restore serum levels of follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH) in POI rats induced by the stress hormone corticosterone and can reduce follicular atresia and improve ovarian function. A mechanistic study also showed that BHD might regulate the expression of Np4 and Angptl 4 to improve corticosterone-induced POI [28].…”

Section: Bhdmentioning

confidence: 99%

Complementary and Alternative Medicine for Premature Ovarian Insufficiency: A Review of Utilization and Mechanisms

Ding

Shen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Premature ovarian insufficiency (POI) is defined as a decline in ovarian function before the age of 40 and is one of the leading causes of infertility in women. The etiology is complex, and the pathogenesis is not clear. The main treatment is hormone replacement therapy, but a growing body of data confirms that such treatment can increase the risk of endometrial disease and cardiovascular disease. Complementary and alternative medicine (CAM) has been widely used in patients with POI due to its limited adverse reactions and high efficiency. According to literature reports, CAM therapy for POI mainly includes traditional Chinese medicine, acupuncture, psychotherapy, dietary supplements, and exercise therapy. This article reviews the application of CAM in the treatment of POI and attempts to determine the therapeutic effects and the mechanisms behind these effects based on existing clinical and experimental studies in order to provide theoretical support for the treatment of POI.

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“…Stress can activate the hypothalamic-pituitary-adrenal axis, leading to prolonged abnormal endocrine hormone levels in women, ultimately resulting in menstrual disorders, infertility, and other reproductive dysfunctions [9]. In animal experiments, chronic stress has been shown to disrupt the estrous cycle, alter hormone levels, and decrease follicle numbers in mice [10,11]. Stress can also induce cytoplasmic fragmentation, apoptosis, spindle disorders, and oxidative stress, accelerating the aging of mouse oocytes and increasing the risk of early pregnancy failure [12].…”

Section: Introductionmentioning

confidence: 99%

The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model

Hong,

Xiao,

Weng

et al. 2024

Preprint

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Studies shows that stress is associated with ovarian dysfunction. Norepinephrine (NE), a classic stress hormone in the stress response, is less recognized for its role in ovarian function. A NE-treated mouse model is induced by intraperitoneal injection of NE for 4 weeks. Compared with the normal control, we find that NE-treated mice show disturbances in the estrous cycle, decreased levels of anti-Mullerian hormone (AMH) and estradiol (E2), and increased levels of follicle-stimulating hormone (FSH). Additionally, the number of primordial follicles, primary follicles, secondary follicles, and antral follicles decreased, while the number of atretic follicles increased in NE-treated mice, indicating NE-induced ovarian dysfunction. RNA sequencing further reveals that genes associated with ferroptosis are significantly enriched in NE-treated ovarian tissues. Concurrently, the content of reactive oxygen species (ROS), ferrous ion, and malondialdehyde (MDA) increased, while the expression level of glutathione peroxidase 4 (GPX4) decreased. To elucidate the mechanism of NE-induced ferroptosis in ovaries and the potential reversal by Coenzyme Q10 (CoQ10), an antioxidant, we conduct both in vitro and in vivo experiments. In vitro, we observe that the granulosa cell line KGN, when treated with NE, shows decreased cell viability, reduced expression of GPX4, elevated ferrous ion and ROS content, and increased MDA levels. However, these NE-induced changes are rescued by the addition of CoQ10. In the mouse model, we find that NE-treated mice supplemented with CoQ10 increased GPX4 levels and decreased the contents of iron, ROS, and MDA compared with the NE group. Moreover, the differential expression of genes associated with ferroptosis induced by NE is ameliorated by CoQ10 in NE-treated mice. Additionally, CoQ10 improved ovarian function, as evidenced by increased ovarian weight, more regular estrous cycles, and an increase in follicles at various stages of growth in NE-treated mice. In conclusion, NE induces ovarian dysfunction by triggering ferroptosis in ovarian tissues, and CoQ10 represents a promising approach for protecting reproductive function by inhibiting ferroptosis.

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Research on the establishment of chronic stress‐induced premature ovarian failure the rat model and effects of Chinese medicine Muniziqi treatment

Cited by 9 publications

References 35 publications

Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure

Beneficial Effects of Traditional Chinese Medicine in the Treatment of Premature Ovarian Failure

Complementary and Alternative Medicine for Premature Ovarian Insufficiency: A Review of Utilization and Mechanisms

The effect of norepinephrine on ovarian dysfunction by mediating ferroptosis in mice model

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