The demand for skilled business professionals has reached unparalleled heights in the context of the constantly globalizing world. The China-Shanghai Cooperation Organization Demonstration Zone for Local Economic and Trade Collaboration in Qingdao (Qingdao SCO demonstration zone) has garnered attention as a prominent hub for fulfilling the growing need in this area. The notion of collaboration between universities and enterprises has become an essential approach, assuming a crucial role in the development of these individuals. The phenomenon described is particularly conspicuous within the domain of cross-border electronic commerce, a sector that is currently undergoing rapid expansion and significant changes. This extensive study delves into the intricate dynamics of university-enterprise cooperation inside the Qingdao SCO demonstration zone. The methodology employed in this study is characterized by its robustness, as it incorporates a comprehensive examination of the available literature, statistical investigations, and real-world implementations of the collaboration model. Notably, there is a particular focus on the city of Qingdao. The research also examines the incorporation of the “industry-university-research” model at a societal level, investigating its ramifications and efficacy of business talent cultivation in the domain of cross-border e-commerce. The initial results of the study underscore the exceptional efficacy of the university-enterprise collaboration paradigm. This model has demonstrated its significance in enhancing students’ understanding of the market, their ability to adapt, and their overall potential for employment. The emerging cross-border e-commerce industry in Qingdao has introduced a new set of demands for skilled professionals in the business sector. These span complex topics such as cross-cultural communication, innovative digital marketing tactics, and a comprehensive awareness of the numerous legal and regulatory frameworks governing e-commerce businesses. In this particular context, the strategy known as “SCO-Integration-Combination” has been introduced as an innovative technique aimed at enhancing the collaboration between academic institutions and enterprises inside the Qingdao SCO demonstration zone. The findings of this study highlight the crucial significance of enhancing partnerships between universities and enterprises in the Qingdao SCO demonstration zone. These strategic relationships serve to accelerate the process of talent development and guarantee a smooth synchronization between educational paradigms and the constantly changing industrial requirements of China, particularly in the dynamic field of cross-border e-commerce.