The abstracted model from engineering practice is the research object in the course of “analog electronic technology”, which has strong theoretical characteristics, abstract and obscure knowledge points, and it is difficult to combine with practice. By adopting the teaching mode of “integration of theory and virtual simulation”, Multisim virtual simulation can effectively solve the phenomenon of disconnection between theory and practice and low enthusiasm of students in previous teaching methods. It combines theoretical mastery with practical application, the students’ subjective initiative is fully mobilized, and the students’ ability is effectively trained and exercised, so the quality of teaching is improved.