Groundwater overexploitation in West Ordos necessitates sustainable irrigation practices. This study evaluated three irrigation levels—W1 (3300 m3 · ha−1), W2 (2850 m3 · ha−1), and W3 (2400 m3 · ha−1)—by modifying the wide-width planting pattern of maize. Additionally, two levels of straw mulch were analyzed: F1 (9000 kg · ha−1) and F2 (no mulch). The study aimed to investigate the effects of these treatments on corn growth dynamics, soil water temperature, soil enzyme activity, yield, grain quality, and water use efficiency. The results indicated a decline in growth indices, enzyme activities, grain quality, and yield under the limited irrigation levels W2 and W3 compared to W1. The highest corn yields were observed with W1F1 (6642.54 kg · ha−1) and W2F1 (6602.38 kg · ha−1), with the latter showing only a 0.6% decrease. Notably, water use efficiency in the W2F1 treatment improved by 4.69%, 12.08%, 10.27%, 12.59%, and 12.96% compared to W1F1, W3F1, W1F2, W2F2, and W3F2, respectively. Straw mulch (F1) significantly elevated the soil temperature, increasing the effective accumulated temperature during the growth period by 10.11~85.79 °C, and boosted the soil enzyme activity by 10–25%. Under limited irrigation, the W2 (2850 m3 · ha−1) and F1 (9000 kg · ha−1 straw) treatments achieved the highest water productivity of 2.48 kg·m−3, maintaining a high yield of 6602.38 kg · ha−1 while preserving nutrients essential to the corn’s quality. This approach presents a viable strategy for wide-width corn planting in groundwater-depleted regions, offering a scientifically grounded and sustainable water management solution for efficient corn production in West Ordos.