We have researched the residual stress in super-smooth glass ceramics using nano-indentation technology, according to the characteristic that the residual stress in the process of pressure is sensitive to the pileup around the indenter, we can determine the changing area, then combine this with the elasto-plastic contact theory, thus the residual stress calculation formula is obtained. By the continuous strain obtained by a spherical indenter and the research on the yield stress and stress-strain curves of microcrystalline glass through spherical indentation experiments, we can get the rule which can tell us how the residual stress of the microcrystalline glass changes with the depth from surface. This research helps to improve the processing quality as well as the performance of the super-smooth surfaced microcrystalline glass, obviously it has a wide application prospect.