In order to better understand the efficiency optimization problem of radio energy transmission systems, the author proposes a genetic algorithm based research on efficiency optimization of radio energy transmission systems. The author first addresses the issue of improving the efficiency of magnetic coupled radio energy transmission. On the basis of ensuring a certain transmission distance and voltage gain, the system is mathematically modeled using coupling circuit theory, and mathematical expressions such as transmission efficiency, transmission distance, and voltage gain are obtained as the objective functions of the algorithm. Secondly, the impact of metal obstacles on the transmission system was analyzed. Design a radio energy transmission compensation circuit, and through simulation, obtain three transmission system parameter schemes that meet the objective function and constraint conditions. Finally, the multi-objective genetic algorithm is used to optimize the system parameter design and obtain the optimal combination of transmission system parameters, with coupling coefficient k=0.1818 and mutual inductance coefficient M=23.165 × 10^(-5) H. Using multi-objective genetic algorithm, the algorithm has a fast convergence function in terms of the number of iterations, a non dominated function solution, and Pareto graphs have verified that the numerical value (3) in the text is the optimal combination design for the transmission system.