The wear and degradation of tools applied in the high-pressure die casting of Al alloys induce significant financial losses. The formation of failures on the surface of mold parts caused by erosion, thermal fatigue, corrosion, and soldering negatively affects the surface quality of castings. In this study, the lifetime of inserts protected by physical-vapor-deposited coatings (TiN, TiAlN, and CrAlSiN) is examined under real manufacturing conditions while considering requirements for the castings’ surface quality (maximum average roughness Ra) defined by the customer. The goal was to identify the most suitable solution for HPDC in the foundry organization. After the deposition of PVD coatings on the inserts, the hardness (HRC) values increased from two to five depending on the coating used, and also the surface roughness was higher in the case of all inserts (Ra values increased from 0.24 to 0.36 µm). The lifetime of all PVD-coated inserts was higher compared to the uncoated insert. The highest lifetime was achieved by the application of a TiN coating, when 15,000 shots were achieved until the inserts’ wear negatively affected (increased) the surface roughness of castings, considering the customer requirements for the maximum Ra value. SEM analysis was used to identify examples of wear and degradation on the surface of the TiN coated insert.