Qinshan nuclear power plant is the first large Chinese-designed nuclear power station based on pressurized water reactor, and the second generation main stream active safety injection system is adopted for Qinshan nuclear power plant. In this paper, a novel passive safety injection system (PSIS) has been proposed for ocean-based Qinshan Phase One nuclear power plant to replace the original active one. The PSIS contains high-pressure, medium-pressure, and lower-pressure safety injection systems, and a two-stage automatic depressurization system. To evaluate the system performance, small-break LOCA has been investigated using RELAP5. Various break sizes and locations including 2-inch, 10-inch cold leg break, and double-ended direct vessel injection line break were analyzed. Key safety parameters such as safe injection mass flow rates, coolant level of the core, system pressure, and fuel cladding temperature were monitored during the accident process. The results illustrate that the performance of the safety injection system can guarantee the effective core cooling and submerged under different LOCA even with only half of the safety injection system, which can fulfill the single failure criteria. The thermal-hydraulic analysis for the Qinshan passive safety injection system is significant to master the related technologies for Chinese engineer and develop the Chinese-designed third-generation nuclear power plants, and the PSIS can guarantee the reactor submerged under LOCA even plus the station block out accident.