Over the past few decades, research has been conducted to develop high-strength concrete (HSC) for high-rise structures and bridge decks. The research discussed in the study focuses on using polyurethane resin (PR) and aramid fibers (AF) to develop HSC, which enhances its strength, durability, and structural properties without increasing the cementitious content. This approach can lead to more sustainable and cost-effective construction practices by reducing the cementitious materials required. In the present investigation, M50-grade concrete mixes were designed in accordance with the guidelines mentioned in Indian Standard (IS) 10262 along with the addition of supplementary cementitious materials, such as fly ash and silica fume. Initially, varying percentages of AF (0% to 3%) and PR (0% to 6%) were added into the concrete mixes and detailed experimental investigations were completed on workability, strength, durability, and structural properties. It is concluded that the addition of AF and PR shows significant improvements in strength, durability, and structural properties compared to traditional HSC created with zero AF and PR content. As reinforced concrete (RC) elements serve as the final product for human construction projects, it is crucial to ensure that their structural properties are reliable. In order to validate the findings from experimental investigations, numerical simulations were conducted using the ANSYS commercial package software. Specifically, the structural properties of RC beams were analyzed using this software, allowing for further validation and verification of the experimental results. From the detailed investigation, it is concluded that 2.5% addition of AF and 4% addition of PR demonstrates better results and is considered the optimum ingredient dosage, which can be used as a reference for future studies and practical applications. These findings can result in the development of new and improved building materials and techniques that can potentially lead to safer, more durable, and sustainable structures.