2022
DOI: 10.1016/j.jacc.2022.09.044
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Research Opportunities in the Treatment of Mitral Valve Prolapse

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Cited by 28 publications
(21 citation statements)
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“…The identification of those at highest risk for ventricular arrhythmia and SCD within the larger population of benign MVP cases remains a major and unmet challenge. 1 Current guidelines focus on management of significant MR, with less emphasis on routine monitoring of ComVE in MVP without MR. 46, 47 In the absence of LGE, arrhythmic risk stratification in MVP is even less clear to the practicing cardiologist. In our study, we demonstrate greater interstitial fibrosis in arrhythmic MVP, regardless of MR or LGE, and more so in women.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The identification of those at highest risk for ventricular arrhythmia and SCD within the larger population of benign MVP cases remains a major and unmet challenge. 1 Current guidelines focus on management of significant MR, with less emphasis on routine monitoring of ComVE in MVP without MR. 46, 47 In the absence of LGE, arrhythmic risk stratification in MVP is even less clear to the practicing cardiologist. In our study, we demonstrate greater interstitial fibrosis in arrhythmic MVP, regardless of MR or LGE, and more so in women.…”
Section: Discussionmentioning
confidence: 99%
“…Mitral valve prolapse (MVP) is a common heritable condition affecting 2% to 3% of individuals worldwide. 1 MVP without significant mitral regurgitation (MR) is generally considered a benign condition. However, a small but non-negligible subset of MVP subjects (0.14% to 1.8% yearly) are at risk of life-threatening arrhythmic events and sudden cardiac death (SCD).…”
Section: Introductionmentioning
confidence: 99%
“…Our findings suggest a potential pathophysiological link between MVP-related mechanical abnormalities and basal wall myocardial fibrosis and generate the hypothesis for association of MVP-related abnormal mechanics with ventricular arrhythmia, which might be potential imaging markers of increased arrhythmic risk. 59 , 60 …”
Section: Discussionmentioning
confidence: 99%
“…If uncertainties persist, transesophageal echocardiography or cardiac magnetic resonance (CMR) can help. On CMR, diffuse interstitial or regional replacement fibrosis by T1 mapping and/or late gadolinium enhancement and edema by T2 mapping can help identify the optimal timing of surgery in MVP complicated by severe DMR ( 19 ).…”
Section: Before Starting All Thinking: Is Mitral Regurgitation Truly ...mentioning
confidence: 99%