Research progress and application opportunities of nanoparticle–protein corona complexes

Quantitative comparison of the protein corona of nanoparticles with different matrices

“…As reported in the literature, apolipoproteins are a major component of the PC independent of the matrix type for all NPs ( Cedervall et al, 2007a ; Charbgoo et al, 2018 ; Huang et al, 2021 ; Lundqvist et al, 2008 ; Tenzer et al, 2011 ; Yu et al, 2020 ). Previous literature has demonstrated that APOs can have a positive effect on the fate of NPs ( Ahsan et al, 2018 ; Kreuter et al, 2002 ; Martínez-Negro et al, 2021 ; Wagner et al, 2012 ).…”

Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes

“…This surface shell is mainly composed of proteins, called “protein corona” (PC). The PC adsorption on nanocarrier surface can affect its physical-chemical properties such as dimensions and ζ-potential that could influence its in vivo behavior and hence its toxicity, in vivo clearance, cellular uptake, cells interaction, and immune response [ 12 ]. Understanding the factors related to the protein corona interaction, it is possible to take advantage of this phenomenon to optimize carrier design, ameliorate its efficiency, targeting and blood residence time.…”

Multivalent ACE2 engineering—A promising pathway for advanced coronavirus nanomedicine development

“… [227] , [228] , [229] , [230] The phenomenon has been critical for both pristine and protein-coated nanoparticle therapeutics due to its complex influence on nanoparticle’s biological activity, pharmacodynamics, safety and ultimate fate in living systems. [231] , [232] , [233] , [234] , [235] , [236] In part, the complexity depends on the size, morphology, surface charge and chemistry of the nanoparticle. [231] , [232] , [233] , [234] , [235] , [236] Similarly, the extend of protein adsorption also depends on the route of nanoparticle delivery (e.g., intravenous or intranasal).…”

“… [231] , [232] , [233] , [234] , [235] , [236] In part, the complexity depends on the size, morphology, surface charge and chemistry of the nanoparticle. [231] , [232] , [233] , [234] , [235] , [236] Similarly, the extend of protein adsorption also depends on the route of nanoparticle delivery (e.g., intravenous or intranasal). [237] , [238] , [239] , [240] These factors, by extension, also modulate the colloidal stability (or agglomeration propensity) of nanomaterials in biological media.…”

“…Fortunately, experiential cues in other nanomedicine studies are available that highlight how the phenomenon could obstruct active-targeting, uptake and the ultimate fate of protein-coated nanomaterials. [236] , [238] , [239] , [240] , [245] , [246] The resulting impact may be complementary or deleterious [247] , [248] , [249] and thus worth examining for appropriate interventions. We anticipate that existing nanoparticle dispersion and stabilization strategies that leverage a careful control of the biophysical properties of phase formations and have been previously demonstrated in other protein-nanoparticle formulations [250] , [251] , [252] , [253] will be useful in circumventing protein corona and colloidal stability challenges in ACE2-based nano-pharmaceuticals.…”