Gas drainage with bedding boreholes is an efficient method for preventing gas and achieving coal and gas comining in underground mining engineering. An underground pressurized drilling method is proposed to maintain the borehole stability. However, the presence of natural fractures in coal seams poses challenges during pressurized drilling. Therefore, it is crucial to establish a low-leadage degradable drilling fluid system that minimizes coal seam damage. In this study, a degradable drilling fluid system was developed based on the characteristics of coal seams. The performance and influencing factors of the drilling fluid and the degrading capability of cellulase were examined. Moreover, the damage of the drilling fluid on fractured coal seams was investigated using core flow test methods. The results showed that additives significantly improved the rheology, filtration, and inhibition of the drilling fluid. The drilling fluid system exhibited excellent stability, rheological properties, low filtration, and sealing performance in coal seam environments. However, drilling fluid invasion and mud cake blockage negatively affected gas flow in fractured coal seams, and a higher content of filtrate reducer hindered the recovery of the gas flow rate. Cellulase was used to degrade polymers and alleviate the challenge of mud cake removal after drilling. Research on the influencing factors of cellulase indicates that the degradation efficiency of cellulase enzymes is influenced by the temperature, pH, salinity, and solid-phase content. For polluted coal samples, the gas flow rate significantly recovered after treatment with a cellulase solution. This study provides insights into a degradable drilling fluid system that can enhance underground pressurized drilling methods and minimize reservoir damage.