Research progress and perspectives of N-methyl-D-aspartate receptor in myocardial and cerebral ischemia-reperfusion injury: A review

Liao, Wei; Wen, Yuehui; Yang, Shaochun; Duan, Yanyu; Liu, Ziyou

doi:10.1097/md.0000000000035490

Cited by 2 publications

(1 citation statement)

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“…Upon neuronal depolarisation, there is an increase in its conductance, allowing for a large calcium influx into the neurons and triggering an even larger release of calcium from intracellular stores. This increase in the cytosolic calcium concentration is a key step in initiating the intracellular pathways for mitochondrial dysfunction, apoptotic cascade responses, inflammatory responses, and reactive oxygen species (ROS) production, ultimately leading to OS-mediated damage [ 7 ].…”

Section: Ischemic Strokementioning

confidence: 99%

Novel Multi-Antioxidant Approach for Ischemic Stroke Therapy Targeting the Role of Oxidative Stress

Briones-Valdivieso,

Briones,

Orellana-Urzúa

et al. 2024

Biomedicines

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Stroke is a major contributor to global mortality and disability. While reperfusion is essential for preventing neuronal death in the penumbra, it also triggers cerebral ischemia-reperfusion injury, a paradoxical injury primarily caused by oxidative stress, inflammation, and blood–brain barrier disruption. An oxidative burst inflicts marked cellular damage, ranging from alterations in mitochondrial function to lipid peroxidation and the activation of intricate signalling pathways that can even lead to cell death. Thus, given the pivotal role of oxidative stress in the mechanisms of cerebral ischemia-reperfusion injury, the reinforcement of the antioxidant defence system has been proposed as a protective approach. Although this strategy has proven to be successful in experimental models, its translation into clinical practice has yielded inconsistent results. However, it should be considered that the availability of numerous antioxidant molecules with a wide range of chemical properties can affect the extent of injury; several groups of antioxidant molecules, including polyphenols, carotenoids, and vitamins, among other antioxidant compounds, can mitigate this damage by intervening in multiple signalling pathways at various stages. Multiple clinical trials have previously been conducted to evaluate these properties using melatonin, acetyl-L-carnitine, chrysanthemum extract, edaravone dexborneol, saffron, coenzyme Q10, and oleoylethanolamide, among other treatments. Therefore, multi-antioxidant therapy emerges as a promising novel therapeutic option due to the potential synergistic effect provided by the simultaneous roles of the individual compounds.

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Section: Ischemic Strokementioning

confidence: 99%