Research Progress and Prospects for Polymeric Nanovesicles in Anticancer Drug Delivery

Abstract

Polymeric vesicles served as the most promising candidates of drug delivery nanocarriers are attracting increasing attention in cancer therapy. Significant advantages have been reported, including hydrophilic molecules with high loading capacity, controllable drug release, rapid and smart responses to stimuli and versatile functionalities. In this study, we have made a systematic review of all aspects of nano-vesicles as drug delivery vectors for cancer treatment, mainly including the following aspect: characteristics of polymeric nanovesicles, polymeric nanovesicle synthesis, and recent progress in applying polymeric nanovesicles in antitumor drug delivery. Polymer nanovesicles have the advantages of synergistic photothermal and imaging in improving the anticancer effect. Therefore, we believe that drug carrier of polymer nanovesicles is a key direction for cancer treatment.

Phenylboronic acid-modified nanoscale multi-arm polymers for tumor-targeted therapy

“…As mentioned above, H22 tumor models were constructed. 13 The NIR-797-labeled nanoparticles were injected into H22 tumor-bearing ICR mice via the tail vein. Fluorescence imaging was conducted at different time points using a Maestro EX fluorescence imaging system (Cambridge Research & Instrumentation, CRi, USA).…”

“…Following published procedures, 13 SH-SY5Y MCs with a diameter of ∼200 μm were co-incubated with the FITC-labeled polymers (0.25 mg mL −1 ) at 37 °C for different periods. Thereafter, the MCs were observed by CLSM after being rinsed three times with PBS ( pH 7.4).…”

“…[9][10][11][12] The polymeric NDDSs used most widely are the nanoassemblies of amphiphilic polymers in an aqueous medium, such as polymer vesicles, micelles and nanoparticles. 13,14 These polymer assemblies have several intrinsic shortcomings, including low stability, wide size and composition distributions, and uncontrollable drug loading and release, which lead to unsatisfactory biological properties. For example, the low stability would cause the premature dissociation of the nanoassemblies in blood circulation, give rise to boosted drug release, and consequently diminish EPR-mediated tumor accumulation, leading to unselective distribution of drugs in the body.…”

Mechanistic Approach of Nano Carriers for Targeted in Cancer Chemotherapy: A Newer Strategy for Novel Drug Delivery System

“…In the modern field of oncology, chemotherapy has been reported to have potential benefits to arrest cancerous cell proliferation, neovascularisation, metastasis in tumor cells as well as the capability to control the growth rate of malignant cells other than any harmful effect of normal healthy cells [1]. Lipid bilayer vesicles are spherical in shape and are constructed with phospholipids and cholesterol, with an aqueous internal compartment.…”

The state of the art in core-shell type lipid polymer hybrid nanocarriers and beyond

“…Unfortunately, they are not free of limitations either. The most important ones are the difficulties in the industrial adaptation of production technologies, the use of organic solvents in the production processes, and the premature release of the therapeutic agent from the carrier [6][7][8].…”